In the hematology and cell therapy department of the EHU-Oran, 330 patients suffering from Hodgkin lymphoma (LH) of extended stages IIB bulky, III and IV, aged 16 to 75 years were treated from Jan. 1st 2004 to Dec. 31st 2019. In this work, we analyze the profile of these patients as well as the...
Over 90% of early-stage Hodgkin lymphomas and nearly 80% of advanced stages achieve long-term disease-free survival. Achieving complete remission remains an important prognostic factor. The aim of this work is to assess the predictive factors for obtaining complete remission in Hodgkin lymphoma after a first line treatment. Patients and methods: In this retrospective study,...
Diffuse large B-cell lymphomas (LDGCB) represent the main form of non-Hodgkin's lymphomas (NHL), they can be ganglionic or extra-ganglionic. These are aggressive lymphomas but can be cured in more than 50% of cases. Their prognosis depends on the expression of their own genomics, they can be of the GC or non-GC subtype, double Hit...
Renal insufficiency (RI) is a common severe complication of symptomatic multiple myeloma (MM), it is related to higher mortality. It is reported in 15 to 40% of patients diagnosed with MM. Its physiopathology is complex; it is associated with multiple and varied underlying mechanisms. Renal involvement is, in the majority of the cases, related...
Purpose: The purpose of this study is to evaluate quality of life (QoL) of chronic myeloid leukaemia patients (CML) receiving tyrosine kinase inhibitors (TKIs), a disease requiring strict daily compliance with taking TKIs orally, as well as regular clinical and biological controls. Methods: The study included 61 patients with CML followed in three hospitals...
Acquired haemophilia is a rare disease. The diagnosis is evoked by the absence of personal and family haemorrhagic history, an isolated prolongation of the aPTT not corrected by the test of the mixture, a decrease in the activity of factor VIII or IX. It’s confirmed by the presence of an autoantibody FVIII or an...
Introduction: In severe haemophilia, a chronic haemophilic arthropathy of the knee is a major and frequent complication. Its involvement must be evaluated clinically, radiologically. Diagnosed at the early stage of synovitis, which is treated by a cortisonic or radioactive synoviorthesis with Yttrium 90. Patients and methods: We included in our study 08 patients...
The SARS-CoV-2 pandemic represents an unprecedented challenge for the medical community. The haematological societies have issued guidelines. We report through this work our experience facing this scourge.
Introduction: Thrombocytopenia is considered among the most serious complications observed during Covid-19. Our objective is to describe the thrombocytopenia observed in patients with Covid-19 at the Oran University Hospital, to interpret the variation of the various platelet parameters in our series and compare our results with other studies. Patients and methods: Our study included...
Non-Hodgkin lymphoma (NHL) is a malignant disease of lymphoid tissue that is increasing in frequency. The aetiology remains unknown to date but a number of factors are implicated in their occurrence. In two thirds of cases these are acquired and therefore modifiable factors. Between January 2015 and April 2019, we collected 301 cases and 302 controls,...
Fabry's disease is an inherited metabolic disease, of transmission linked to the X chromosome, is due to a total or partial deficiency of a lysosomal enzyme, alpha-galactosidase-A. From an early age, it leads to a progressive ubiquitous accumulation of glycosphingolipids (mainly globotriaosylceramide also called GL-3, or Gb3) not degraded by this enzyme. Cutaneous, neurological,...
